Nature Communications (Feb 2016)

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

  • Chloé Lescale,
  • Vincent Abramowski,
  • Marie Bedora-Faure,
  • Valentine Murigneux,
  • Gabriella Vera,
  • David B. Roth,
  • Patrick Revy,
  • Jean-Pierre de Villartay,
  • Ludovic Deriano

DOI
https://doi.org/10.1038/ncomms10529
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.