Nature Communications (Feb 2016)
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
Abstract
Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.