Communications Biology (Feb 2021)
Global mapping of protein–metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity
- Marcin Luzarowski,
- Rubén Vicente,
- Andrei Kiselev,
- Mateusz Wagner,
- Dennis Schlossarek,
- Alexander Erban,
- Leonardo Perez de Souza,
- Dorothee Childs,
- Izabela Wojciechowska,
- Urszula Luzarowska,
- Michał Górka,
- Ewelina M. Sokołowska,
- Monika Kosmacz,
- Juan C. Moreno,
- Aleksandra Brzezińska,
- Bhavana Vegesna,
- Joachim Kopka,
- Alisdair R. Fernie,
- Lothar Willmitzer,
- Jennifer C. Ewald,
- Aleksandra Skirycz
Affiliations
- Marcin Luzarowski
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Rubén Vicente
- Department of Metabolic Networks, Max Planck Institute of Molecular Plant Physiology
- Andrei Kiselev
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Mateusz Wagner
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Dennis Schlossarek
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Alexander Erban
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Leonardo Perez de Souza
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Dorothee Childs
- Department of Genome Biology, European Molecular Biology Laboratory
- Izabela Wojciechowska
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Urszula Luzarowska
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Michał Górka
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Ewelina M. Sokołowska
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Monika Kosmacz
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Juan C. Moreno
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Aleksandra Brzezińska
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Bhavana Vegesna
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Joachim Kopka
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Alisdair R. Fernie
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Lothar Willmitzer
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- Jennifer C. Ewald
- Interfaculty Institute of Cell Biology, Eberhard Karls University of Tuebingen
- Aleksandra Skirycz
- Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology
- DOI
- https://doi.org/10.1038/s42003-021-01684-3
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 15
Abstract
Marcin Luzarowski et al. use a new method PROMIS for systematic analysis of protein small molecule interactions in yeast. Their work provides an experimentally-derived catalogue of protein–metabolite complexes in S. cerevisiae and reveals that the Ser-Leu dipeptide activates Pgk1, and alters cellular metabolism.
