Vitamin D metabolites and the gut microbiome in older men

Robert L. Thomas; Lingjing Jiang; John S. Adams; Zhenjiang Zech Xu; Jian Shen; Stefan Janssen; Gail Ackermann; Dirk Vanderschueren; Steven Pauwels; Rob Knight; Eric S. Orwoll; Deborah M. Kado

doi:10.1038/s41467-020-19793-8

Nature Communications (Nov 2020)

Vitamin D metabolites and the gut microbiome in older men

Robert L. Thomas,
Lingjing Jiang,
John S. Adams,
Zhenjiang Zech Xu,
Jian Shen,
Stefan Janssen,
Gail Ackermann,
Dirk Vanderschueren,
Steven Pauwels,
Rob Knight,
Eric S. Orwoll,
Deborah M. Kado

Affiliations

Robert L. Thomas: Department of Medicine, University of California San Diego
Lingjing Jiang: Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego
John S. Adams: Departments of Orthopaedic Surgery and Molecular, Cell and Developmental Biology at UCLA
Zhenjiang Zech Xu: State Key Laboratory of Food Science and Technology, Nanchang University
Jian Shen: Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego
Stefan Janssen: Algorithmic Bioinformatics, Department of Biology and Chemistry, Justus-Liebig-University
Gail Ackermann: Department of Pediatrics, University of California San Diego
Dirk Vanderschueren: Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Laboratory of Clinical and Experimental Endocrinology, KU Leuven
Steven Pauwels: Department of Laboratory Medicine, University Hospitals Leuven
Rob Knight: Department of Pediatrics, University of California San Diego
Eric S. Orwoll: Department of Medicine, Bone and Mineral Unit, Oregon Health & Sciences University
Deborah M. Kado: Department of Medicine, University of California San Diego

DOI: https://doi.org/10.1038/s41467-020-19793-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Here, the authors investigate associations of vitamin D metabolites with gut microbiome in a cross-sectional analysis of 567 elderly men enrolled in the Osteoporotic Fractures in Men (MrOS) Study and find larger alpha-diversity correlates with high 1,25(OH)2D and high 24,25(OH)2D and higher ratios of activation and catabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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