Pleiotropic effects of the HMG-CoA reductase inhibitors

Abstract

Christos G Mihos, Orlando SantanaColumbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USAAbstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to further elucidate this interesting phenomenon.Keywords: HMG-CoA inhibitors, pleiotropic, reductase, review, statins