Derivation of iPSC lines from three young healthy donors of Caucasian origin (NUIGi035-A; NUIGi036-A; NUIGi037-A)

Yicheng Ding; Berta Marcó de la Cruz; Veronica McInerney; Yin Lu; Guangming Yang; Xiaohong Qian; Weidong Li; Janusz Krawczyk; Linda Howard; Timothy O'Brien; Louise Gallagher; Sanbing Shen

Stem Cell Research (Dec 2020)

Derivation of iPSC lines from three young healthy donors of Caucasian origin (NUIGi035-A; NUIGi036-A; NUIGi037-A)

Yicheng Ding,
Berta Marcó de la Cruz,
Veronica McInerney,
Yin Lu,
Guangming Yang,
Xiaohong Qian,
Weidong Li,
Janusz Krawczyk,
Linda Howard,
Timothy O'Brien,
Louise Gallagher,
Sanbing Shen

Affiliations

Yicheng Ding: Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI) Galway, Ireland
Berta Marcó de la Cruz: Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI) Galway, Ireland
Veronica McInerney: HRB Clinical Research Facility, National University of Ireland (NUI) Galway, Ireland
Yin Lu: School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China
Guangming Yang: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
Xiaohong Qian: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Proteomics, Beijing, China
Weidong Li: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China
Janusz Krawczyk: Department of Haematology, Galway University Hospital, Ireland
Linda Howard: Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI) Galway, Ireland
Timothy O'Brien: Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI) Galway, Ireland; CÚRAM, National University of Ireland (NUI) Galway, Ireland
Louise Gallagher: Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland; Corresponding authors at: Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, Dangan, Upper Newcastle, National University of Ireland Galway, Galway, Ireland (S. Shen).
Sanbing Shen: Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI) Galway, Ireland; FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland; Corresponding authors at: Regenerative Medicine Institute, School of Medicine, Biomedical Science Building BMS-1021, Dangan, Upper Newcastle, National University of Ireland Galway, Galway, Ireland (S. Shen).

Journal volume & issue: Vol. 49
p. 102101

Abstract

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The induced pluripotent stem cell (iPSC) technology has offered an unprecedented opportunity for disease modelling and drug discovery. Here we used non-integrating Sendai viral method and derived iPSCs from three young healthy Caucasian donors. All iPSCs expressed pluripotency markers highly and could be differentiated into three germ lineages. They possess normal karyotype which was confirmed by whole genome SNP array. The availability of the healthy control iPSCs offers an opportunity for phenotypic comparison and genome editing for a variety of diseases.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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