EUS-guided through-the-needle biopsy for pancreatic cystic lesions

Jason Samarasena, MD; Allen Yu, BSc; David Lee, MD; Rintaro Hashimoto, MD; Yuxin Lu, MD; Daniel Thieu, BSc; Daniel Mai, BSc; John Lee, MD; Kenneth Chang, MD

VideoGIE (Sep 2019)

EUS-guided through-the-needle biopsy for pancreatic cystic lesions

Jason Samarasena, MD,
Allen Yu, BSc,
David Lee, MD,
Rintaro Hashimoto, MD,
Yuxin Lu, MD,
Daniel Thieu, BSc,
Daniel Mai, BSc,
John Lee, MD,
Kenneth Chang, MD

Affiliations

Jason Samarasena, MD: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
Allen Yu, BSc: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
David Lee, MD: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
Rintaro Hashimoto, MD: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
Yuxin Lu, MD: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
Daniel Thieu, BSc: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
Daniel Mai, BSc: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
John Lee, MD: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA
Kenneth Chang, MD: H. H. Chao Comprehensive Digestive Disease Center, University of California – Irvine, Orange, California, USA

Journal volume & issue: Vol. 4, no. 9
pp. 436 – 439

Abstract

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Background and Aims: Differentiating pancreatic cystic lesions remains a challenge when the current technique of EUS-guided FNA is used. Recently, a miniaturized biopsy forceps with an outer diameter of 0.8 mm has been developed, thus allowing it to be passed through the bore of a standard 19-gauge FNA needle to acquire tissue. Methods: This study consisted of a retrospective review of all cases of EUS-guided through-the-needle forceps biopsy technique (TTNFB) performed for pancreatic cystic lesions at a single academic tertiary care center over a 12-month period. Technical success was defined as acquisition of adequate tissue for formal histologic analysis. Safety was assessed through the monitoring and recording of periprocedural and postprocedural adverse events. Results: The technical success of EUS-guided TTNFB was 87% (13/15). EUS-guided TTNFB with histologic analysis yielded pancreatic cyst diagnoses in 11 of 15 (73%) patients, compared with 0 of 15 (0%) patients with the use of EUS-FNA and cytologic analysis (P < .001). Of the 15 cystic lesions, 8 were diagnosed as intrapapillary mucinous neoplasm based on EUS-TTNFB. Conclusion: This TTNFB technique has the potential to improve the diagnostic yield of EUS-FNA for pancreatic cystic neoplasms.

Published in VideoGIE

ISSN: 2468-4481 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.sciencedirect.com/journal/videogie

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