Clinical, Cosmetic and Investigational Dermatology (2021-01-01)

Fixed Cutaneous Sporotrichosis Due to Sporothrix globosa

  • Liu F,
  • Liu Y,
  • Yuan N,
  • Zhang X,
  • Cao M,
  • Dong J,
  • Zhang J

Journal volume & issue
Vol. Volume 14
pp. 91 – 96


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Fang Liu,1 Yingmei Liu,2 Na Yuan,1 Xiuying Zhang,1 Mei Cao,1 Jie Dong,1 Jinqing Zhang1 1Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of ChinaCorrespondence: Fang LiuDepartment of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Road, Beijing 100020, People’s Republic of ChinaTel +86-18611369216Email [email protected]: This report describes a case of a skin sporotrichosis infection and the steps taken to identify an effective antifungal treatment.Patients and Methods: A 50-year-old woman from Jilin province, China, presented complaining of a small mass that had been on her right upper eyelid for two years. A skin biopsy was taken and submitted for bacterial and mycological assessment. Bacterial culture from the lesion was negative, but a fungal culture was positive. In vitro susceptibility test was performed to assess its susceptibility to antifungal drugs.Results: The skin biopsy showed infectious granuloma. Fungal culture was identified as Sporothrix globosa based on both the morphological features and confirmation by the molecular method; it was resistant to many kinds of antifungal drugs, including amphotericin B, voriconazole, fluconazole, and caspofungin. However, it was relatively sensitive to itraconazole. The patient was prescribed 0.2 g itraconazole to be taken twice per day. One month later, she had almost completely recovered from her symptoms. The treatment lasted for 3 months and her liver function and renal function were normal at the endpoint.Conclusion: Itraconazole was an effective treatment in this case of a multidrug-resistant sporotrichosis caused by S. globosa.Keywords: fixed cutaneous sporotrichosis, Sporothrix globosa