Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Mar 2022)

Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

  • Cyril Camaro,
  • Judith L. Bonnes,
  • Eddy M. Adang,
  • Eva M. Spoormans,
  • Gladys N. Janssens,
  • Nina W. van der Hoeven,
  • Lucia S. Jewbali,
  • Eric A. Dubois,
  • Martijn Meuwissen,
  • Tom A. Rijpstra,
  • Hans A. Bosker,
  • Michiel J. Blans,
  • Gabe B. Bleeker,
  • Rémon Baak,
  • George J. Vlachojannis,
  • Bob J. Eikemans,
  • Pim van der Harst,
  • Iwan C. van der Horst,
  • Michiel Voskuil,
  • Joris J. van der Heijden,
  • Bert Beishuizen,
  • Martin Stoel,
  • Hans van der Hoeven,
  • José P. Henriques,
  • Alexander P. Vlaar,
  • Maarten A. Vink,
  • Bas van den Bogaard,
  • Ton A. Heestermans,
  • Wouter de Ruijter,
  • Thijs S. Delnoij,
  • Harry J. Crijns,
  • Gillian A. Jessurun,
  • Pranobe V. Oemrawsingh,
  • Marcel T. Gosselink,
  • Koos Plomp,
  • Michael Magro,
  • Paul W. Elbers,
  • Peter M. van de Ven,
  • Jorrit S. Lemkes,
  • Niels van Royen

DOI
https://doi.org/10.1161/JAHA.121.022238
Journal volume & issue
Vol. 11, no. 5

Abstract

Read online

Background In patients with out‐of‐hospital cardiac arrest without ST‐segment elevation, immediate coronary angiography did not improve clinical outcomes when compared with delayed angiography in the COACT (Coronary Angiography After Cardiac Arrest) trial. Whether 1 of the 2 strategies has benefits in terms of health care resource use and costs is currently unknown. We assess the health care resource use and costs in patients with out‐of‐hospital cardiac arrest. Methods and Results A total of 538 patients were randomly assigned to a strategy of either immediate or delayed coronary angiography. Detailed health care resource use and cost‐prices were collected from the initial hospital episode. A generalized linear model and a gamma distribution were performed. Generic quality of life was measured with the RAND‐36 and collected at 12‐month follow‐up. Overall total mean costs were similar between both groups (EUR 33 575±19 612 versus EUR 33 880±21 044; P=0.86). Generalized linear model: (β, 0.991; 95% CI, 0.894–1.099; P=0.86). Mean procedural costs (coronary angiography and percutaneous coronary intervention, coronary artery bypass graft) were higher in the immediate angiography group (EUR 4384±3447 versus EUR 3028±4220; P<0.001). Costs concerning intensive care unit and ward stay did not show any significant difference. The RAND‐36 questionnaire did not differ between both groups. Conclusions The mean total costs between patients with out‐of‐hospital cardiac arrest randomly assigned to an immediate angiography or a delayed invasive strategy were similar during the initial hospital stay. With respect to the higher invasive procedure costs in the immediate group, a strategy awaiting neurological recovery followed by coronary angiography and planned revascularization may be considered. Registration URL: https://trialregister.nl; Unique identifier: NL4857.

Keywords