Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release

Piersandro Pallavicini; Barbara Bassi; Giuseppe Chirico; Maddalena Collini; Giacomo Dacarro; Emiliano Fratini; Pietro Grisoli; Maddalena Patrini; Laura Sironi; Angelo Taglietti; Marcel Moritz; Ioritz Sorzabal-Bellido; Arturo Susarrey-Arce; Edward Latter; Alison J. Beckett; Ian A. Prior; Rasmita Raval; Yuri A. Diaz Fernandez

doi:10.1038/s41598-017-05693-3

Scientific Reports (Jul 2017)

Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release

Piersandro Pallavicini,
Barbara Bassi,
Giuseppe Chirico,
Maddalena Collini,
Giacomo Dacarro,
Emiliano Fratini,
Pietro Grisoli,
Maddalena Patrini,
Laura Sironi,
Angelo Taglietti,
Marcel Moritz,
Ioritz Sorzabal-Bellido,
Arturo Susarrey-Arce,
Edward Latter,
Alison J. Beckett,
Ian A. Prior,
Rasmita Raval,
Yuri A. Diaz Fernandez

Affiliations

Piersandro Pallavicini: Department of Chemistry and Centre for Health Technology, University of Pavia
Barbara Bassi: Department of Chemistry and Centre for Health Technology, University of Pavia
Giuseppe Chirico: Department of Physics, University Milano-Bicocca
Maddalena Collini: Department of Physics, University Milano-Bicocca
Giacomo Dacarro: Department of Chemistry and Centre for Health Technology, University of Pavia
Emiliano Fratini: Department of Chemistry “Ugo Schiff” and CSGI, University of Florence
Pietro Grisoli: Department of Pharmaceutical Sciences, University of Pavia
Maddalena Patrini: Department of Physics, University of Pavia
Laura Sironi: Department of Physics, University Milano-Bicocca
Angelo Taglietti: Department of Chemistry and Centre for Health Technology, University of Pavia
Marcel Moritz: Open Innovation Hub for Antimicrobial Surfaces, University of Liverpool
Ioritz Sorzabal-Bellido: Open Innovation Hub for Antimicrobial Surfaces, University of Liverpool
Arturo Susarrey-Arce: Open Innovation Hub for Antimicrobial Surfaces, University of Liverpool
Edward Latter: Open Innovation Hub for Antimicrobial Surfaces, University of Liverpool
Alison J. Beckett: Biomedical EM Unit, School of Biomedical Sciences, University of Liverpool
Ian A. Prior: Biomedical EM Unit, School of Biomedical Sciences, University of Liverpool
Rasmita Raval: Open Innovation Hub for Antimicrobial Surfaces, University of Liverpool
Yuri A. Diaz Fernandez: Open Innovation Hub for Antimicrobial Surfaces, University of Liverpool

DOI: https://doi.org/10.1038/s41598-017-05693-3
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Abstract Photo-responsive antibacterial surfaces combining both on-demand photo-switchable activity and sustained biocidal release were prepared using sequential chemical grafting of nano-objects with different geometries and functions. The multi-layered coating developed incorporates a monolayer of near-infrared active silica-coated gold nanostars (GNS) decorated by silver nanoparticles (AgNP). This modular approach also enables us to unravel static and photo-activated contributions to the overall antibacterial performance of the surfaces, demonstrating a remarkable synergy between these two mechanisms. Complementary microbiological and imaging evaluations on both planktonic and surface-attached bacteria provided new insights on these distinct but cooperative effects.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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