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Effect of Na2SO3 concentration to drug loading and drug release of ascorbic acid in chitosan edible film as drug delivery system membrane

MATEC Web of Conferences. 2018;154:01026 DOI 10.1051/matecconf/201815401026


Journal Homepage

Journal Title: MATEC Web of Conferences

ISSN: 2261-236X (Online)

Publisher: EDP Sciences

LCC Subject Category: Technology: Engineering (General). Civil engineering (General)

Country of publisher: France

Language of fulltext: French, English

Full-text formats available: PDF



Kistriyani Lilis

Yulianto Muhammad Farid

Prasetya Y. Rifqi


Editorial review

Editorial Board

Instructions for authors

Time From Submission to Publication: 6 weeks


Abstract | Full Text

Chitosan is a type of carbohydrate compounds produced from waste marine products, in particular the class of shrimp, crabs and clams. Chitosan is often process into edible films and utilized for food packaging also has potential as a membrane for drug delivery system. Drug loading and drug release can be controlled by improve the characteristics of the membrane by adding crosslinker. The purpose of this research is to study the effect of addition of crosslinker to the rate of loading and release of ascorbic acid in the chitosan edible film. Na2SO3 was used as crosslinker. Two grams of chitosan was dissolved into 100 ml of distilled water. Acetic acid and plasticizer were added in the solution then heated at 50°C. Na2SO3 solution with mass various of Na2SO3 dissolved, 01026 0.3; and 0.5 grams were added about 30 mL to make edible film. The analysis include of drug loading, drug release and tensile strength. The result showed that the loading of edible film with crosslinker 0.15 g; 0.3 g; and 0.5 g respectively were 60.98 ppm; 52.53 ppm; and 40.88 ppm, meanwhile for the release with crosslinker 0.15 g; 0.3 g; and 0.5 g respectively were 3.78 ppm; 5.72 ppm; and 5.97 ppm.