Nature Communications (Apr 2017)
An extra-uterine system to physiologically support the extreme premature lamb
- Emily A. Partridge,
- Marcus G. Davey,
- Matthew A. Hornick,
- Patrick E. McGovern,
- Ali Y. Mejaddam,
- Jesse D. Vrecenak,
- Carmen Mesas-Burgos,
- Aliza Olive,
- Robert C. Caskey,
- Theodore R. Weiland,
- Jiancheng Han,
- Alexander J. Schupper,
- James T. Connelly,
- Kevin C. Dysart,
- Jack Rychik,
- Holly L. Hedrick,
- William H. Peranteau,
- Alan W. Flake
Affiliations
- Emily A. Partridge
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Marcus G. Davey
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Matthew A. Hornick
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Patrick E. McGovern
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Ali Y. Mejaddam
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Jesse D. Vrecenak
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Carmen Mesas-Burgos
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Aliza Olive
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Robert C. Caskey
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Theodore R. Weiland
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Jiancheng Han
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Alexander J. Schupper
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- James T. Connelly
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Kevin C. Dysart
- Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia
- Jack Rychik
- Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia
- Holly L. Hedrick
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- William H. Peranteau
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- Alan W. Flake
- Department of Surgery, Center for Fetal Research, The Children’s Hospital of Philadelphia Research Institute
- DOI
- https://doi.org/10.1038/ncomms15112
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The ability to support the development of a premature fetus in the form of an extracorporeal system has had limited success. Here, the authors show that an extra-uterine device that mimics the intra-uterine environment can provide physiologic support for the extreme premature lamb fetus for four weeks.
