Comparison between transtracheal and intravenous 2% lignocaine in attenuating hemodynamic stress response following direct laryngoscopy and endotracheal intubation: a randomized controlled trial

Abstract

Abstract Background and aims Lignocaine is used through various routes to mitigate the hemodynamic surge associated with laryngoscopy and endotracheal intubation during general anesthesia. This study hypothesized that post-induction administration of transtracheal 2% lignocaine at 1.5 mg/kg would have a similar effect to intravenous 2% lignocaine at the same dosage, providing an alternative for attenuating the hemodynamic stress response. Methods A total of 138 consenting patients were randomized into two groups. Following induction, Group IV patients received 2% lignocaine at 1.5 mg/kg intravenously, while Group TT patients received 2% lignocaine at 1.5 mg/kg transtracheally. The primary outcome was the comparison of hemodynamic responses at different time points around intubation. The secondary outcome was the incidence of sore throat. Data analyses were done using the Statistical Software Jupyter Notebook, running in a Python 3.11 environment. Results Post-induction hypotension was significantly less pronounced in the TT group [Mean blood pressure (median with IQR) IV group 68(60-78) mm of Hg vs. TT group 71(66-82.25) mm of Hg, P = 0.018]. TT group patients experienced a significantly smaller post-intubation surge at 3 minutes in blood pressure and heart rate compared to the IV group [Mean blood pressure (median with IQR) IV group 79(71-87) mm of Hg vs. TT group 73(65-81) mm of Hg, P = 0.009 and Heart rate (median with IQR) IV group 80(70-94) per minute vs. 71.5(64-82.75) per minute P = 0.015]. Conclusion Transtracheal lignocaine is more likely to maintain stable hemodynamics during intubation compared to intravenous lignocaine. Trial registration CTRI/2023/06/054125 [Registered on: 19/06/2023]. This trial is registered with the Clinical Trial Registry of India https://ctri.nic.in/Clinicaltrials/login.php .

Keywords

• Transtracheal Injection
• Tracheal Intubation
• Hemodynamics