Nature Communications (Apr 2024)
The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus
- Annefleur C. Langedijk,
- Bram Vrancken,
- Robert Jan Lebbink,
- Deidre Wilkins,
- Elizabeth J. Kelly,
- Eugenio Baraldi,
- Abiel Homero Mascareñas de Los Santos,
- Daria M. Danilenko,
- Eun Hwa Choi,
- María Angélica Palomino,
- Hsin Chi,
- Christian Keller,
- Robert Cohen,
- Jesse Papenburg,
- Jeffrey Pernica,
- Anne Greenough,
- Peter Richmond,
- Federico Martinón-Torres,
- Terho Heikkinen,
- Renato T. Stein,
- Mitsuaki Hosoya,
- Marta C. Nunes,
- Charl Verwey,
- Anouk Evers,
- Leyla Kragten-Tabatabaie,
- Marc A. Suchard,
- Sergei L. Kosakovsky Pond,
- Chiara Poletto,
- Vittoria Colizza,
- Philippe Lemey,
- Louis J. Bont,
- on behalf of the INFORM-RSV Study Group
Affiliations
- Annefleur C. Langedijk
- Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre Utrecht
- Bram Vrancken
- Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology
- Robert Jan Lebbink
- Department of Medical Microbiology, University Medical Center Utrecht
- Deidre Wilkins
- Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca
- Elizabeth J. Kelly
- Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca
- Eugenio Baraldi
- Department of Woman’s and Child’s Health, University Hospital of Padova
- Abiel Homero Mascareñas de Los Santos
- Jose Eluterio Gonzalez Hospital Universitario
- Daria M. Danilenko
- Smorodintsev Research Institute of Influenza
- Eun Hwa Choi
- Seoul National University Children’s Hospital
- María Angélica Palomino
- Hospital Roberto del Río, Universidad de Chile
- Hsin Chi
- MacKay Children’s Hospital
- Christian Keller
- Institute of Virology, University Hospital Giessen and Marburg
- Robert Cohen
- Université Paris XII
- Jesse Papenburg
- McGill University Health Centre
- Jeffrey Pernica
- McMaster University
- Anne Greenough
- ReSViNET Foundation
- Peter Richmond
- University of Western Australia
- Federico Martinón-Torres
- ReSViNET Foundation
- Terho Heikkinen
- ReSViNET Foundation
- Renato T. Stein
- ReSViNET Foundation
- Mitsuaki Hosoya
- Fukushima Medical University School of Medicine
- Marta C. Nunes
- ReSViNET Foundation
- Charl Verwey
- Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand
- Anouk Evers
- Department of Medical Microbiology, University Medical Center Utrecht
- Leyla Kragten-Tabatabaie
- ReSViNET Foundation
- Marc A. Suchard
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Sergei L. Kosakovsky Pond
- Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University
- Chiara Poletto
- INSERM, Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique IPLESP
- Vittoria Colizza
- INSERM, Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique IPLESP
- Philippe Lemey
- Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology
- Louis J. Bont
- Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre Utrecht
- on behalf of the INFORM-RSV Study Group
- DOI
- https://doi.org/10.1038/s41467-024-47118-6
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 12
Abstract
Abstract Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.
