Inhale, exhale: Why particulate matter exposure in animal models are so acute? Data and facts behind the history
Flávio Curbani,
Fernanda de Oliveira Busato,
Maynara Marcarini do Nascimento,
David Nicholas Olivieri,
Carlos Eduardo Tadokoro
Affiliations
Flávio Curbani
Programa de Pós-Graduação em Ecologia de Ecossistemas, Universidade Vila Velha, Rua Comissário José Dantas de Melo, 21, Boa Vista, CEP 29102-920, Vila Velha, ES, Brazil; Departamento de Tecnologia Industrial, Centro Tecnológico, Universidade Federal do Espírito Santo, Av. Fernando Ferrari, 514, Goiabeiras, CEP 29060-970, Vitória, ES, Brazil
Fernanda de Oliveira Busato
Laboratory of Immunobiology, Universidade Vila Velha, Rua Comissário José Dantas de Melo, 21, Boa Vista, CEP 29102-920, Vila Velha, ES, Brazil
Maynara Marcarini do Nascimento
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Rua Comissário José Dantas de Melo, 21, Boa Vista, CEP 29102-920, Vila Velha, ES, Brazil
David Nicholas Olivieri
Escuela Superior de Ingeniería Informatica, University of Vigo, Spain
Carlos Eduardo Tadokoro
Programa de Pós-Graduação em Ecologia de Ecossistemas, Universidade Vila Velha, Rua Comissário José Dantas de Melo, 21, Boa Vista, CEP 29102-920, Vila Velha, ES, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Rua Comissário José Dantas de Melo, 21, Boa Vista, CEP 29102-920, Vila Velha, ES, Brazil; Corresponding author. Programa de Pós-Graduação em Ecologia de Ecossistemas, Universidade Vila Velha, Rua Comissário José Dantas de Melo, 21, Boa Vista, CEP 29102-920, Vila Velha, ES, Brazil.
We present a dataset obtained by extracting information from an extensive literature search of toxicological experiments using mice and rat animal models to study the effects of exposure to airborne particulate matter (PM). Our dataset covers results reported from 75 research articles considering paper published in 2017 and seminal papers from previous years. The compiled data and normalization were processed with an equation based on a PM dosimetry model. This equation allows the comparison of different toxicological experiments using instillation and inhalation as PM exposure protocols with respect to inhalation rates, concentrations and PM exposure doses of the toxicological experiments performed by different protocols using instillation and inhalation PM as exposure methods. This data complements the discussions and interpretations presented in the research article “Inhale, exhale: why particulate matter exposure in animal models are so acute?” Curbani et al., 2019. Keywords: Concentration, Dose, Health effects, Inhalation rate, Instillation, Toxicology
