Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope

Johana Torralba; Igor de la Arada; Angélica Partida-Hanon; Edurne Rujas; Madalen Arribas; Sara Insausti; Claire Valotteau; Javier Valle; David Andreu; José M. M. Caaveiro; María Angeles Jiménez; Beatriz Apellániz; Lorena Redondo-Morata; José L. Nieva

doi:10.1038/s42003-022-04219-6

Communications Biology (Nov 2022)

Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope

Johana Torralba,
Igor de la Arada,
Angélica Partida-Hanon,
Edurne Rujas,
Madalen Arribas,
Sara Insausti,
Claire Valotteau,
Javier Valle,
David Andreu,
José M. M. Caaveiro,
María Angeles Jiménez,
Beatriz Apellániz,
Lorena Redondo-Morata,
José L. Nieva

Affiliations

Johana Torralba: Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU)
Igor de la Arada: Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU)
Angélica Partida-Hanon: Institute of Physical Chemistry “Rocasolano” (IQFR-CSIC)
Edurne Rujas: Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU)
Madalen Arribas: Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU)
Sara Insausti: Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU)
Claire Valotteau: Laboratoire Adhesion et Inflammation, INSERM U1067, CNRS UMR 7333, Aix-Marseille Université, Turing Centre for Living systems
Javier Valle: Laboratory of Proteomics and Protein Chemistry, Department of Medicine and Life Sciences, Pompeu Fabra University
David Andreu: Laboratory of Proteomics and Protein Chemistry, Department of Medicine and Life Sciences, Pompeu Fabra University
José M. M. Caaveiro: Laboratory of Global Healthcare, School of Pharmaceutical Sciences, Kyushu University
María Angeles Jiménez: Institute of Physical Chemistry “Rocasolano” (IQFR-CSIC)
Beatriz Apellániz: Department of Physiology, Faculty of Pharmacy, University of the Basque Country (UPV/EHU)
Lorena Redondo-Morata: Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille
José L. Nieva: Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU)

DOI: https://doi.org/10.1038/s42003-022-04219-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

The molecular recognition of the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein in membrane mimetics is characterised to help shape continued development of more efficient and stable anti-MPER vaccines.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal