Haematologica (Jun 2018)
A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features
- Keisuke Kawamoto,
- Hiroaki Miyoshi,
- Takaharu Suzuki,
- Yasuji Kozai,
- Koji Kato,
- Masaharu Miyahara,
- Toshiaki Yujiri,
- Ilseung Choi,
- Katsumichi Fujimaki,
- Tsuyoshi Muta,
- Masaaki Kume,
- Sayaka Moriguchi,
- Shinobu Tamura,
- Takeharu Kato,
- Hiroyuki Tagawa,
- Junya Makiyama,
- Yuji Kanisawa,
- Yuya Sasaki,
- Daisuke Kurita,
- Kyohei Yamada,
- Joji Shimono,
- Hirohito Sone,
- Jun Takizawa,
- Masao Seto,
- Hiroshi Kimura,
- Koichi Ohshima
Affiliations
- Keisuke Kawamoto
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan;Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
- Hiroaki Miyoshi
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- Takaharu Suzuki
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan;Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
- Yasuji Kozai
- Department of Hematology, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan
- Koji Kato
- Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
- Masaharu Miyahara
- Department of Hematology, Karatsu Red Cross Hospital, Japan
- Toshiaki Yujiri
- Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan
- Ilseung Choi
- Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
- Katsumichi Fujimaki
- Department of Hematology, Fujisawa City Hospital, Japan
- Tsuyoshi Muta
- Department of Hematology, Japan Community Health Care Organization Kyushu Hospital, Japan
- Masaaki Kume
- Department of Hematology, Hiraka General Hospital, Yokote, Japan
- Sayaka Moriguchi
- Department of Pathology, Miyazaki University, Japan
- Shinobu Tamura
- Department of Hematology and Oncology, Wakayama Medical University, Japan
- Takeharu Kato
- Department of Hematology, Sasebo City General Hospital, Japan
- Hiroyuki Tagawa
- Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
- Junya Makiyama
- Department of Hematology, National Hospital Organization Nagasaki Medical Center, Omura, Japan
- Yuji Kanisawa
- Department of Hematology and Oncology, Oji General Hospital, Tomakomai, Japan
- Yuya Sasaki
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- Daisuke Kurita
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- Kyohei Yamada
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- Joji Shimono
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- Hirohito Sone
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
- Jun Takizawa
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
- Masao Seto
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- Hiroshi Kimura
- Department of Virology, Faculty of Medicine, Nagoya University, Japan
- Koichi Ohshima
- Department of Pathology, Kurume University School of Medicine, Niigata University, Japan
- DOI
- https://doi.org/10.3324/haematol.2017.174177
- Journal volume & issue
-
Vol. 103,
no. 6
Abstract
The characteristics of adult patients with chronic active Epstein-Barr virus infection are poorly recognized, hindering early diagnosis and an improved prognosis. We studied 54 patients with adult-onset chronic active Epstein-Barr virus infection diagnosed between 2005 and 2015. Adult onset was defined as an estimated age of onset of 15 years or older. To characterize the clinical features of these adults, we compared them to those of 75 pediatric cases (estimated age of onset
