Nature Communications (Sep 2020)
Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
- Sara R. Rashkin,
- Rebecca E. Graff,
- Linda Kachuri,
- Khanh K. Thai,
- Stacey E. Alexeeff,
- Maruta A. Blatchins,
- Taylor B. Cavazos,
- Douglas A. Corley,
- Nima C. Emami,
- Joshua D. Hoffman,
- Eric Jorgenson,
- Lawrence H. Kushi,
- Travis J. Meyers,
- Stephen K. Van Den Eeden,
- Elad Ziv,
- Laurel A. Habel,
- Thomas J. Hoffmann,
- Lori C. Sakoda,
- John S. Witte
Affiliations
- Sara R. Rashkin
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Rebecca E. Graff
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Linda Kachuri
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Khanh K. Thai
- Division of Research, Kaiser Permanente Northern California
- Stacey E. Alexeeff
- Division of Research, Kaiser Permanente Northern California
- Maruta A. Blatchins
- Division of Research, Kaiser Permanente Northern California
- Taylor B. Cavazos
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Douglas A. Corley
- Division of Research, Kaiser Permanente Northern California
- Nima C. Emami
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Joshua D. Hoffman
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Eric Jorgenson
- Division of Research, Kaiser Permanente Northern California
- Lawrence H. Kushi
- Division of Research, Kaiser Permanente Northern California
- Travis J. Meyers
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Stephen K. Van Den Eeden
- Division of Research, Kaiser Permanente Northern California
- Elad Ziv
- Institute for Human Genetics, University of California, San Francisco
- Laurel A. Habel
- Division of Research, Kaiser Permanente Northern California
- Thomas J. Hoffmann
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Lori C. Sakoda
- Division of Research, Kaiser Permanente Northern California
- John S. Witte
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- DOI
- https://doi.org/10.1038/s41467-020-18246-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals of European ancestry across 18 cancer types from two large cohorts.
