Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Mayumi Sugita; Roman Galetto; Hongliang Zong; Nathan Ewing-Crystal; Vicenta Trujillo-Alonso; Nuria Mencia-Trinchant; Winnie Yip; Stephanie Filipe; Celine Lebuhotel; Agnès Gouble; Duane C. Hassane; Julianne Smith; Gail J. Roboz; Monica L. Guzman

doi:10.1038/s41467-022-29668-9

Nature Communications (Apr 2022)

Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Mayumi Sugita,
Roman Galetto,
Hongliang Zong,
Nathan Ewing-Crystal,
Vicenta Trujillo-Alonso,
Nuria Mencia-Trinchant,
Winnie Yip,
Stephanie Filipe,
Celine Lebuhotel,
Agnès Gouble,
Duane C. Hassane,
Julianne Smith,
Gail J. Roboz,
Monica L. Guzman

Affiliations

Mayumi Sugita: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Roman Galetto: Cellectis SA
Hongliang Zong: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Nathan Ewing-Crystal: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Vicenta Trujillo-Alonso: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Nuria Mencia-Trinchant: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Winnie Yip: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Stephanie Filipe: Cellectis SA
Celine Lebuhotel: Cellectis SA
Agnès Gouble: Cellectis SA
Duane C. Hassane: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Julianne Smith: Cellectis SA
Gail J. Roboz: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College
Monica L. Guzman: Division of Hematology and Oncology, Department of Medicine. Weill Cornell Medical College

DOI: https://doi.org/10.1038/s41467-022-29668-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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CD123, the interleukin-3 receptor alpha chain, is aberrantly expressed in acute myeloid leukemia blasts and leukemia stem cells. Here the authors report the design and characterize the anti-tumor activity of allogeneic CD123-targeted CAR-T cells as a therapeutic approach for acute myeloid leukemia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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