Communications Biology (May 2022)
Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program
- Ani Manichaikul,
- Honghuang Lin,
- Chansuk Kang,
- Chaojie Yang,
- Stephen S. Rich,
- Kent D. Taylor,
- Xiuqing Guo,
- Jerome I. Rotter,
- W. Craig Johnson,
- Elaine Cornell,
- Russell P. Tracy,
- J. Peter Durda,
- Yongmei Liu,
- Ramachandran S. Vasan,
- L. Adrienne Cupples,
- Robert E. Gerszten,
- Clary B. Clish,
- Deepti Jain,
- Matthew P. Conomos,
- Thomas Blackwell,
- George J. Papanicolaou,
- Annabelle Rodriguez
Affiliations
- Ani Manichaikul
- Center for Public Heath Genomics, University of Virginia
- Honghuang Lin
- Department of Medicine, University of Massachusetts Medical School
- Chansuk Kang
- Center for Public Heath Genomics, University of Virginia
- Chaojie Yang
- Center for Public Heath Genomics, University of Virginia
- Stephen S. Rich
- Center for Public Heath Genomics, University of Virginia
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- W. Craig Johnson
- University of Washington
- Elaine Cornell
- University of Vermont
- Russell P. Tracy
- University of Vermont
- J. Peter Durda
- University of Vermont
- Yongmei Liu
- Duke University
- Ramachandran S. Vasan
- Department of Medicine, University of Massachusetts Medical School
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Robert E. Gerszten
- Department of Medicine, Beth Israel Deaconess Medical Center
- Clary B. Clish
- Metabolite Profiling, Broad Institute
- Deepti Jain
- University of Washington
- Matthew P. Conomos
- University of Washington
- Thomas Blackwell
- University of Michigan
- George J. Papanicolaou
- National Institutes of Health
- Annabelle Rodriguez
- Center for Vascular Biology, University of Connecticut Health
- DOI
- https://doi.org/10.1038/s42003-022-03304-0
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
Rodriguez et al. use whole genome sequencing and plasma proteomics from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study (FHS) cohorts of the Trans-Omics for Precision Medicine program and perform in situ Hi-C chromatin capture in cell lines isolated from four MESA participants. They demonstrate that lymphocyte activation gene-3 protein networks are associated with HDL-cholesterol and mortality, which could guide the development of precision medicine.
