Present and Future Use of Exosomes in Dermatology

Abstract

Exposure to external environmental stimuli can lead to skin aging, pigmentation, hair loss, and various immune-mediated as well as connective tissue diseases. Although conventional treatments are routinely used and favoured, they fail to achieve an adequate balance between clinical and cosmetic outcomes. Exosomes are vesicles with a lipid bilayer released by several cell types. These bioactive vesicles play a crucial role in intercellular communication and in several other physiological and pathological processes. They serve as vehicles for bioactive substances including lipids, nucleic acids, and proteins, making them appealing as cell-free treatments. According to studies, exosomes play a vital role in preventing scarring, and senescence, and promoting wound healing. Moreover, research on the biology of exosomes is growing, which has enabled the creation of specific guidelines and quality control methodologies to support their potential implementation in the future. In this review, we have mainly focused on the role of exosomes in various dermatological diseases, their clinical applications, and the potential for further research pertaining to this.

Keywords

• exosomes
• stem cell therapy
• skin rejuvenation
• regenerative medicine