Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF

Siyang Guo; Olga S. Sokolova; Johnson Chung; Shae Padrick; Jeff Gelles; Bruce L. Goode

doi:10.1038/s41467-018-05260-y

Nature Communications (Jul 2018)

Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF

Siyang Guo,
Olga S. Sokolova,
Johnson Chung,
Shae Padrick,
Jeff Gelles,
Bruce L. Goode

Affiliations

Siyang Guo: Department of Biology, Brandeis University
Olga S. Sokolova: Department of Biology, Moscow M.V. Lomonosov University
Johnson Chung: Department of Biochemistry, Brandeis University
Shae Padrick: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine
Jeff Gelles: Department of Biochemistry, Brandeis University
Bruce L. Goode: Department of Biology, Brandeis University

DOI: https://doi.org/10.1038/s41467-018-05260-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Abp1, a type II actin nucleation promoting factor, is a known component of branched actin networks but its mechanism remains poorly understood. Here, the authors find that Abp1 enhances Arp2/3-mediated actin branch formation, and blocks ‘debranching’ by GMF, making it a pro-branching factor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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