Nature Communications (Mar 2020)
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
- Matthias Arnold,
- Kwangsik Nho,
- Alexandra Kueider-Paisley,
- Tyler Massaro,
- Kevin Huynh,
- Barbara Brauner,
- Siamak MahmoudianDehkordi,
- Gregory Louie,
- M. Arthur Moseley,
- J. Will Thompson,
- Lisa St John-Williams,
- Jessica D. Tenenbaum,
- Colette Blach,
- Rui Chang,
- Roberta D. Brinton,
- Rebecca Baillie,
- Xianlin Han,
- John Q. Trojanowski,
- Leslie M. Shaw,
- Ralph Martins,
- Michael W. Weiner,
- Eugenia Trushina,
- Jon B. Toledo,
- Peter J. Meikle,
- David A. Bennett,
- Jan Krumsiek,
- P. Murali Doraiswamy,
- Andrew J. Saykin,
- Rima Kaddurah-Daouk,
- Gabi Kastenmüller
Affiliations
- Matthias Arnold
- Department of Psychiatry and Behavioral Sciences, Duke University
- Kwangsik Nho
- Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease Center, Indiana University School of Medicine
- Alexandra Kueider-Paisley
- Department of Psychiatry and Behavioral Sciences, Duke University
- Tyler Massaro
- Duke Clinical Research Institute, Duke University
- Kevin Huynh
- Metabolomics Laboratory, Baker Heart and Diabetes Institute
- Barbara Brauner
- Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Siamak MahmoudianDehkordi
- Department of Psychiatry and Behavioral Sciences, Duke University
- Gregory Louie
- Department of Psychiatry and Behavioral Sciences, Duke University
- M. Arthur Moseley
- Duke Proteomics and Metabolomics Shared Resource, Center for Genomic and Computational Biology, Duke University
- J. Will Thompson
- Duke Proteomics and Metabolomics Shared Resource, Center for Genomic and Computational Biology, Duke University
- Lisa St John-Williams
- Duke Proteomics and Metabolomics Shared Resource, Center for Genomic and Computational Biology, Duke University
- Jessica D. Tenenbaum
- Department of Biostatistics and Bioinformatics, Duke University
- Colette Blach
- Duke Molecular Physiology Institute, Duke University
- Rui Chang
- Center for Innovation in Brain Science, University of Arizona
- Roberta D. Brinton
- Center for Innovation in Brain Science, University of Arizona
- Rebecca Baillie
- Rosa & Co LLC
- Xianlin Han
- University of Texas Health Science Center at San Antonio
- John Q. Trojanowski
- Department of Pathology & Laboratory Medicine, University of Pennsylvania
- Leslie M. Shaw
- Department of Pathology & Laboratory Medicine, University of Pennsylvania
- Ralph Martins
- School of Medical and Health Sciences, Edith Cowan University
- Michael W. Weiner
- Center for Imaging of Neurodegenerative Diseases, Department of Radiology, San Francisco VA Medical Center/University of California San Francisco
- Eugenia Trushina
- Department of Neurology, Mayo Clinic
- Jon B. Toledo
- Department of Pathology & Laboratory Medicine, University of Pennsylvania
- Peter J. Meikle
- Metabolomics Laboratory, Baker Heart and Diabetes Institute
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Jan Krumsiek
- Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine
- P. Murali Doraiswamy
- Department of Psychiatry and Behavioral Sciences, Duke University
- Andrew J. Saykin
- Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease Center, Indiana University School of Medicine
- Rima Kaddurah-Daouk
- Department of Psychiatry and Behavioral Sciences, Duke University
- Gabi Kastenmüller
- Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health
- DOI
- https://doi.org/10.1038/s41467-020-14959-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites in serum.
