PLoS ONE (Jan 2023)

Health-related quality of life of daily-life-affected benign essential blepharospasm: Multi-center observational study.

  • Parima Hirunwiwatkul,
  • Wajamon Supawatjariyakul,
  • Supharat Jariyakosol,
  • Supanut Apinyawasisuk,
  • Jiruth Sriratanaban,
  • Yuda Chongpison,
  • Priya Jagota,
  • Nipat Aui-Aree,
  • Juthamat Witthayaweerasak,
  • Suwanna Setthawatcharawanich,
  • Kitthisak Kitthaweesin,
  • Niphon Chirapapaisan,
  • Piyawadee Chaimongkoltrakul,
  • Poramaet Laowanapiban,
  • Linda Hansapinyo,
  • Suthida Panpitpat,
  • Sireedhorn Kurathong,
  • Jirat Nimworaphan,
  • Suntaree Thitiwichienlert,
  • Kavin Vanikieti,
  • Narong Samipak,
  • Worapot Srimanan,
  • Nattapong Mekhasingharak,
  • Pareena Chaitanuwong

DOI
https://doi.org/10.1371/journal.pone.0283111
Journal volume & issue
Vol. 18, no. 3
p. e0283111

Abstract

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PurposeTo compare Thais' health-related quality of life (HRQOL) and severity grading, efficacy and safety in daily-life-affected benign essential blepharospasm (BEB) patients at baseline and after Botulinum toxin type A (BTX-A) treatment.DesignProspective-observational study.ParticipantsBEB patients with Jankovic rating scale (JRS) at least 3 in both severity and frequency graded from 14 institutes nationwide were included from August 2020 to June 2021.MethodsDemographic data, HRQOL evaluated by the Thai version of EQ-5D-5L and NEI-VFQ-25 questionnaires, and severity grading score evaluated by Jankovic rating scale (JRS) at baseline, 1, and 3 months after the treatment were collected. The impact of the BTX-A injections and their complications were recorded.Results184 daily-life-affected BEB patients were enrolled; 159 patients (86.4%) had complete data with a mean age of 61.40±10.09 years. About 88.05% were female, and 10.1% were newly diagnosed. Most of the patients had bilateral involvement (96.9%) and 12.6% had history of BEB-related accident. After BTX-A treatment, HRQOL improved significantly in 4 dimensions of EQ-5D-5L, except self-care. The EQ_VAS (mean±SD) was 64.54±19.27, 75.13±15.37, 73.8±15.85 (pConclusionDaily-life-affected BEB impacted HRQOL in most dimensions from both generic and visual-specific questionnaires. BTX-A treatment not only decreased disease severity, but also improved quality of life.