Association between Fecal Microbiota, SCFA, Gut Integrity Markers and Depressive Symptoms in Patients Treated in the Past with Bariatric Surgery—The Cross-Sectional Study
Natalia Komorniak,
Alexandra Martynova-Van Kley,
Armen Nalian,
Michał Wroński,
Krzysztof Kaseja,
Bartosz Kowalewski,
Karolina Kaźmierczak-Siedlecka,
Igor Łoniewski,
Mariusz Kaczmarczyk,
Konrad Podsiadło,
Paweł Bogdański,
Joanna Palma,
Ewa Stachowska
Affiliations
Natalia Komorniak
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland
Alexandra Martynova-Van Kley
Department of Biology, Stephen F. Austin State University, Nacogdoches, TX 75962, USA
Armen Nalian
Department of Biology, Stephen F. Austin State University, Nacogdoches, TX 75962, USA
Michał Wroński
Department of Psychiatry, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland
Krzysztof Kaseja
Department of General Surgery and Transplantation, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland
Bartosz Kowalewski
Independent Provincial Public Hospital Complex in Szczecin-Zdunowo, 70-891 Szczecin, Poland
Karolina Kaźmierczak-Siedlecka
Department of Medical Laboratory Diagnostics, Farhenheit Biobank BBMRI.pl. 80-214 Gdańsk, Poland
Igor Łoniewski
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland
(1) Background: Depressive symptoms often appear after surgical treatment. (2) Methods: We involved 41 adults who underwent bariatric surgery a minimum of 6 months before the study and had the Beck scale ≥12. We analysed patients’ mental state, gut barrier markers, faecal short chain fatty acids, and microbiota. (3) Results: Gut microbiota composition differed significantly among patients undergoing two different types of surgery (F = 1.64, p = 0.00002). Additionally, we discovered an association between short chain fatty acids and the Beck scale (F = 1.22, p = 0.058). The rearrangement of bacterial metabolites may be due to the patients’ use of increased dietary protein, with insufficient intake of products containing vegetable fiber (Diet Quality Index (DQI-I )adequacy 22.55 (±3.46) points). (4) Conclusions: Bariatric surgery affects the gut microbiota, which may play an important role in the development of depressive and gastrointestinal symptoms in patients after bariatric surgery. Low fiber consumption and increased levels of faecal isobutyric acid may lead to intestinal inflammation. There is a need for further research on this topic including a larger sample size.
