The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion

Marco Padilla-Rodriguez; Sara S. Parker; Deanna G. Adams; Thomas Westerling; Julieann I. Puleo; Adam W. Watson; Samantha M. Hill; Muhammad Noon; Raphael Gaudin; Jesse Aaron; Daoqin Tong; Denise J. Roe; Beatrice Knudsen; Ghassan Mouneimne

doi:10.1038/s41467-018-05367-2

Nature Communications (Jul 2018)

The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion

Marco Padilla-Rodriguez,
Sara S. Parker,
Deanna G. Adams,
Thomas Westerling,
Julieann I. Puleo,
Adam W. Watson,
Samantha M. Hill,
Muhammad Noon,
Raphael Gaudin,
Jesse Aaron,
Daoqin Tong,
Denise J. Roe,
Beatrice Knudsen,
Ghassan Mouneimne

Affiliations

Marco Padilla-Rodriguez: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona
Sara S. Parker: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona
Deanna G. Adams: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona
Thomas Westerling: Department of Medical Oncology, Division of Molecular and Cellular Oncology, and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute and Harvard Medical School
Julieann I. Puleo: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona
Adam W. Watson: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona
Samantha M. Hill: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona
Muhammad Noon: BioComputing Facility, University of Arizona
Raphael Gaudin: INSERM U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
Jesse Aaron: Advanced Imaging Center, Howard Hughes Medical Institute
Daoqin Tong: School of Geography and Development, College of Social and Behavioral Sciences, University of Arizona
Denise J. Roe: University of Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, University of Arizona
Beatrice Knudsen: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Ghassan Mouneimne: Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona

DOI: https://doi.org/10.1038/s41467-018-05367-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Whilst estrogen is known to be tumorigenic in some breast cancer, in some contexts it can be protective against invasion and dissemination. Here, the authors show estrogen can promote generation of Suppressive Cortical Actin Bundles that can inhibit motility dynamics through EVL-mediated actin cytoskeletal remodeling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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