CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY IN CHILDREN: DIAGNOSIS AND TREATMENT

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) in children is a rare autoimmune disease of the peripheral nervous system. The article analyzes current international diagnostic criteria and clinical presentation features of the disease in childhood. The article discusses general principles of CIDP treatment and focuses on the pathogenetic therapies: intravenous immunotherapy using a standard human immunoglobulin (IVIG) with the content of IgG > 95%, prescription of large doses of glucocorticoids and plasmapheresis. It analyzes the recommendations for prioritizing the use of different types of treatment when initiating the therapy and describes the main drug prescription protocols and recommended doses. Two clinical cases of CIDP in children are described. It is shown that the use of adequate doses of IVIG, glucocorticoids and long-term maintenance treatment can completely reverse the symptoms of peripheral lesion, prevent repeated exacerbations of the disease and significantly improve the quality of life.

Keywords

• хроническая воспалительная демиелинизирующая полинейропатия
• диагностика
• электромиография
• внутривенный иммуноглобулин
• кортикостероиды
• преднизолон
• плазмаферез
• иммуносупрессоры