Clinical, Cosmetic and Investigational Dermatology (May 2021)

Seasonal Variation of Psoriasis and Its Impact in the Therapeutic Management: A Retrospective Study on Chinese Patients

  • Zheng X,
  • Wang Q,
  • Luo Y,
  • Lu W,
  • Jin L,
  • Chen M,
  • Zhu W,
  • Kuang Y

Journal volume & issue
Vol. Volume 14
pp. 459 – 465

Abstract

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Xuanwei Zheng,1– 3,* Qiaolin Wang,1– 3,* Yan Luo,1– 3 Wenhua Lu,1– 3 Liping Jin,1– 3 Menglin Chen,1– 3 Wu Zhu,1– 3 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, 410008, People’s Republic of China; 3Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis (Xiangya Hospital), Changsha, 410008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wu Zhu; Yehong KuangXiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaTel +86-13319509308; +86-13574171102Email [email protected]; [email protected]: The seasonal patterns of psoriasis have been observed in previous studies. However, no published data indicated the risk factors associated with the seasonal variation.Purpose: This study aimed to investigate potentially related factors associated with seasonal pattern of psoriasis and provide possible implications for alleviating psoriasis in clinical practice.Patients and Methods: The retrospective study was conducted in Chinese patients with psoriasis. Demographic and clinical information were collected. Multivariable logistic regression analyses (calculating adjusted odds ratios [AORs]) were used to analyze data.Results: We continually enrolled 2270 patients (1496 males and 774 females) with psoriasis based on inclusion criteria. Disease duration (AOR=1.06, 95% CI: 1.05– 1.07), hyperlipidemia (AOR=1.77, 95% CI: 1.06– 2.98) and smoking (AOR=1.40, 95% CI: 1.17– 1.68) were significantly associated with severe psoriasis in autumn/winter. Age (AOR=0.98, 95% CI:0.97– 0.99) and occupations with more sunlight exposure (AOR=0.78, 95% CI: 0.61– 0.99) were negatively associated with the seasonal aggravation. Subgroup analysis showed that occupations with more sunlight exposure (AOR=0.64, 95% CI: 0.43– 0.94) were protective factors only in late-onset psoriasis but not early-onset, while smoking (AOR=1.39, 95% CI: 1.11– 1.74) was risk factor in the early-onset psoriasis.Conclusion: Psoriatic patients who had occupation with more sunlight exposure were less likely to report aggravation of psoriasis in autumn/winter. On the contrary, smoking and hyperlipidemia were positively associated with the seasonal aggravation. Additional prospective study is needed to identify the causality.Keywords: psoriasis, seasonal variation, weather, occupational exposure, ultraviolet, smoking

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