Cardiovascular Biomarkers in Cardio-Oncology: Antineoplastic Drug Cardiotoxicity and Beyond
Umberto Attanasio,
Elena Di Sarro,
Lucia Tricarico,
Daniela Di Lisi,
Giuseppe Armentaro,
Sofia Miceli,
Francesco Fioretti,
Martino Deidda,
Michele Correale,
Giuseppina Novo,
Angela Sciacqua,
Savina Nodari,
Christian Cadeddu,
Carlo Gabriele Tocchetti,
Alberto Palazzuoli,
Valentina Mercurio
Affiliations
Umberto Attanasio
Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
Elena Di Sarro
Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
Lucia Tricarico
Cardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy
Daniela Di Lisi
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
Giuseppe Armentaro
Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100 Catanzaro, Italy
Sofia Miceli
Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100 Catanzaro, Italy
Francesco Fioretti
Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Spedali Civili Hospital and University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy
Martino Deidda
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy
Michele Correale
Cardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy
Giuseppina Novo
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
Angela Sciacqua
Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100 Catanzaro, Italy
Savina Nodari
Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Spedali Civili Hospital and University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy
Christian Cadeddu
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy
Carlo Gabriele Tocchetti
Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
Alberto Palazzuoli
Cardiovascular Diseases Unit, Cardio-thoracic and Vascular Department Le Scotte Hospital, University of Siena, Strada delle Scotte 14, 53100 Siena, Italy
Valentina Mercurio
Department of Translational Medical Sciences, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
Serum biomarkers represent a reproducible, sensitive, minimally invasive and inexpensive method to explore possible adverse cardiovascular effects of antineoplastic treatments. They are useful tools in risk stratification, the early detection of cardiotoxicity and the follow-up and prognostic assessment of cancer patients. In this literature review, we aim at describing the current state of knowledge on the meaning and the usefulness of cardiovascular biomarkers in patients with cancer; analyzing the intricate relationship between cancer and cardiovascular disease (especially HF) and how this affects cardiovascular and tumor biomarkers; exploring the role of cardiovascular biomarkers in the risk stratification and in the identification of chemotherapy-induced cardiotoxicity; and providing a summary of the novel potential biomarkers in this clinical setting.
