Nature Communications (Mar 2022)

Structural basis for modulation of human NaV1.3 by clinical drug and selective antagonist

  • Xiaojing Li,
  • Feng Xu,
  • Hao Xu,
  • Shuli Zhang,
  • Yiwei Gao,
  • Hongwei Zhang,
  • Yanli Dong,
  • Yanchun Zheng,
  • Bei Yang,
  • Jianyuan Sun,
  • Xuejun Cai Zhang,
  • Yan Zhao,
  • Daohua Jiang

DOI
https://doi.org/10.1038/s41467-022-28808-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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NaV1.3 is involved in neuronal development, hormone secretion and pain perception. Here, the authors elucidate the molecular mechanism for modulation of NaV1.3 by a site-2 neurotoxin bulleyaconitine A and a subtype selective antagonist ICA121431.