Nature Communications (Jul 2019)
The nasal methylome as a biomarker of asthma and airway inflammation in children
- Andres Cardenas,
- Joanne E. Sordillo,
- Sheryl L. Rifas-Shiman,
- Wonil Chung,
- Liming Liang,
- Brent A. Coull,
- Marie-France Hivert,
- Peggy S. Lai,
- Erick Forno,
- Juan C. Celedón,
- Augusto A. Litonjua,
- Kasey J. Brennan,
- Dawn L. DeMeo,
- Andrea A. Baccarelli,
- Emily Oken,
- Diane R. Gold
Affiliations
- Andres Cardenas
- Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley
- Joanne E. Sordillo
- Department of Population Medicine, Division of Chronic Disease Research Across the Lifecourse, Harvard Medical School and Harvard Pilgrim Health Care Institute
- Sheryl L. Rifas-Shiman
- Department of Population Medicine, Division of Chronic Disease Research Across the Lifecourse, Harvard Medical School and Harvard Pilgrim Health Care Institute
- Wonil Chung
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Liming Liang
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Brent A. Coull
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Marie-France Hivert
- Department of Population Medicine, Division of Chronic Disease Research Across the Lifecourse, Harvard Medical School and Harvard Pilgrim Health Care Institute
- Peggy S. Lai
- Massachusetts General Hospital, Pulmonary/Critical Care
- Erick Forno
- Division of Pediatric Pulmonary Medicine, University of Pittsburgh School of Medicine
- Juan C. Celedón
- Division of Pediatric Pulmonary Medicine, University of Pittsburgh School of Medicine
- Augusto A. Litonjua
- Division of Pediatric Pulmonary Medicine, University of Rochester Medical Center
- Kasey J. Brennan
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University
- Dawn L. DeMeo
- Department of Medicine, Brigham and Women’s Hospital, Channing Division of Network Medicine, Harvard Medical School
- Andrea A. Baccarelli
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University
- Emily Oken
- Department of Population Medicine, Division of Chronic Disease Research Across the Lifecourse, Harvard Medical School and Harvard Pilgrim Health Care Institute
- Diane R. Gold
- Department of Medicine, Brigham and Women’s Hospital, Channing Division of Network Medicine, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-11058-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Epigenetic differences in nasal epithelium have been proposed as a biomarker for lower airway disease and asthma. Here, in epigenome-wide association studies for asthma and other airway traits using nasal swabs, the authors identify differentially methylated CpGs that highlight genes involved in TH2 response.
