Communications Biology (Jun 2021)

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

  • Joseph Dowsett,
  • Egil Ferkingstad,
  • Line Jee Hartmann Rasmussen,
  • Lise Wegner Thørner,
  • Magnús K. Magnússon,
  • Karen Sugden,
  • Gudmar Thorleifsson,
  • Mike Frigge,
  • Kristoffer Sølvsten Burgdorf,
  • Sisse Rye Ostrowski,
  • Erik Sørensen,
  • Christian Erikstrup,
  • Ole Birger Pedersen,
  • Thomas Folkmann Hansen,
  • Karina Banasik,
  • Søren Brunak,
  • DBDS Genomic Consortium,
  • Vinicius Tragante,
  • Sigrun Helga Lund,
  • Lilja Stefansdottir,
  • Bjarni Gunnarson,
  • Richie Poulton,
  • Louise Arseneault,
  • Avshalom Caspi,
  • Terrie E. Moffitt,
  • Daníel Gudbjartsson,
  • Jesper Eugen-Olsen,
  • Hreinn Stefánsson,
  • Kári Stefánsson,
  • Henrik Ullum

DOI
https://doi.org/10.1038/s42003-021-02144-8
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker.