Nature Communications (Jan 2018)
Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
- Peer Aramillo Irizar,
- Sascha Schäuble,
- Daniela Esser,
- Marco Groth,
- Christiane Frahm,
- Steffen Priebe,
- Mario Baumgart,
- Nils Hartmann,
- Shiva Marthandan,
- Uwe Menzel,
- Jule Müller,
- Silvio Schmidt,
- Volker Ast,
- Amke Caliebe,
- Rainer König,
- Michael Krawczak,
- Michael Ristow,
- Stefan Schuster,
- Alessandro Cellerino,
- Stephan Diekmann,
- Christoph Englert,
- Peter Hemmerich,
- Jürgen Sühnel,
- Reinhard Guthke,
- Otto W. Witte,
- Matthias Platzer,
- Eytan Ruppin,
- Christoph Kaleta
Affiliations
- Peer Aramillo Irizar
- Research Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel
- Sascha Schäuble
- Jena University Language and Information Engineering Lab, Friedrich-Schiller-University Jena
- Daniela Esser
- Research Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel
- Marco Groth
- GerontoSys JenAge Consortium
- Christiane Frahm
- GerontoSys JenAge Consortium
- Steffen Priebe
- GerontoSys JenAge Consortium
- Mario Baumgart
- GerontoSys JenAge Consortium
- Nils Hartmann
- GerontoSys JenAge Consortium
- Shiva Marthandan
- GerontoSys JenAge Consortium
- Uwe Menzel
- GerontoSys JenAge Consortium
- Jule Müller
- Hans Berger Department of Neurology, Jena University Hospital
- Silvio Schmidt
- GerontoSys JenAge Consortium
- Volker Ast
- Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital
- Amke Caliebe
- Institute for Medical Informatics and Statistics, Christian-Albrechts-University Kiel
- Rainer König
- Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital
- Michael Krawczak
- Institute for Medical Informatics and Statistics, Christian-Albrechts-University Kiel
- Michael Ristow
- GerontoSys JenAge Consortium
- Stefan Schuster
- GerontoSys JenAge Consortium
- Alessandro Cellerino
- GerontoSys JenAge Consortium
- Stephan Diekmann
- GerontoSys JenAge Consortium
- Christoph Englert
- GerontoSys JenAge Consortium
- Peter Hemmerich
- GerontoSys JenAge Consortium
- Jürgen Sühnel
- GerontoSys JenAge Consortium
- Reinhard Guthke
- GerontoSys JenAge Consortium
- Otto W. Witte
- GerontoSys JenAge Consortium
- Matthias Platzer
- GerontoSys JenAge Consortium
- Eytan Ruppin
- Department of Computer Science and Center for Bioinformatics and Computational Biology, University of Maryland
- Christoph Kaleta
- Research Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel
- DOI
- https://doi.org/10.1038/s41467-017-02395-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer.
