Comparative estimation of salivary and serum C-reactive protein levels in chronic periodontitis with or without Type II diabetes mellitus: A clinico-biochemical study

Abstract

Background: Periodontal diseases are characterized by chronic inflammatory destruction of periodontal connective tissues and extensive alveolar bone destruction as a result of complex interactions between periodontal pathogens and host defense mechanism. Systemic disease such as diabetes mellitus further aggravated the inflammatory condition. Creactive protein (CRP) elevation is a part of the acute phase response to inflammation. CRP, a proinflammatory mediator level has shown to be elevated in patients with chronic periodontitis. Hence, this study was carried out to compare the level of salivary and serum CRP levels in chronic periodontitis with or without typeII diabetes mellitus. Materials and Methods: A total of 60 patients were selected and divided into three groups: 20 periodontally healthy patients, 20 patients with periodontitis, and 20 periodontitis patients associated with diabetes mellitus. The saliva and serum sample were collected from all patients and estimation of CRP level was done using AVITEX® TURBO CRP kit, and latex particle quantitative turbid metric method was employed. Results: The result showed that salivary and serum CRP level was highest in diabetes mellitus with periodontitis patients as compared to chronic periodontitis and healthy patients. Conclusion: We can conclude that CRP is a potential proinflammatory biomarker in patients with chronic periodontitis and diabetes mellitus.

Keywords

• c-reactive protein level
• diabetes mellitus
• periodontal diseases
• saliva
• serum