Nature Communications (May 2018)

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

  • Laura Vera-Ramirez,
  • Suman K. Vodnala,
  • Ryan Nini,
  • Kent W. Hunter,
  • Jeffrey E. Green

DOI
https://doi.org/10.1038/s41467-018-04070-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Highly metastatic dormant cancer cells contribute to breast cancer recurrence, but the underlying mechanism is less understood. Here, the authors show that dormant breast cancer cells depend on autophagy to ensure their long term survival and distant recurrence