Molecules (Dec 2012)

Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and Their Mutagenic Activity

  • Wagner Vilegas,
  • Lourdes Campaner dos Santos,
  • Paulo Takeo Sano,
  • Samara Fernandes de Souza,
  • Eliana Aparecida Varanda,
  • Paula Karina Boldrin,
  • Fabiana Volpe Zanutto

DOI
https://doi.org/10.3390/molecules18010244
Journal volume & issue
Vol. 18, no. 1
pp. 244 – 262

Abstract

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A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds. The methanol extracts of the capitulae and scapes of P. chiquitensis exhibited mutagenic activity in the Salmonella/microsome assay, against strain TA97a.

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