BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Maija Castrén; Katariina E Lampinen; Riitta Miettinen; Eija Koponen; Ilkka Sipola; Cathy E Bakker; Ben A Oostra; Eero Castrén

Neurobiology of Disease (Oct 2002)

BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Maija Castrén,
Katariina E Lampinen,
Riitta Miettinen,
Eija Koponen,
Ilkka Sipola,
Cathy E Bakker,
Ben A Oostra,
Eero Castrén

Affiliations

Maija Castrén: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Katariina E Lampinen: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Riitta Miettinen: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Eija Koponen: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Ilkka Sipola: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Cathy E Bakker: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Ben A Oostra: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Eero Castrén: Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Neurology, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Psychiatry, University of Kuopio, FIN-70210, Kuopio, Finland; Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands

Journal volume & issue: Vol. 11, no. 1
pp. 221 – 229

Abstract

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Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions. We have investigated whether FMRP and BDNF are reciprocally regulated in neurons. Exposure of cultured hippocampal neurons to BDNF, but not to NT-3, reduced FMR1 mRNA levels to 84.8% of control at 4 h and the levels were back to baseline by 24 h or 4 days. Furthermore, expression of FMR1 mRNA was reduced (82.4% of control) in vivo in the hippocampus of transgenic mice overexpressing TrkB receptors, and a small but significant (5.1%) decrease was also detected in FMRP protein levels. In contrast, the expression patterns of BDNF and TrkB mRNAs were not altered in FMRP-deficient mice compared to wild-type mice. Our data provide evidence that BDNF via TrkB signaling decreases FMRP expression and suggest a role for FMRP in BDNF-induced synaptic plasticity.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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