Nature Communications (Oct 2021)

TRIP6 functions in brain ciliogenesis

  • Shalmali Shukla,
  • Ronny Haenold,
  • Pavel Urbánek,
  • Lucien Frappart,
  • Shamci Monajembashi,
  • Paulius Grigaravicius,
  • Sigrun Nagel,
  • Woo Kee Min,
  • Alicia Tapias,
  • Olivier Kassel,
  • Heike Heuer,
  • Zhao-Qi Wang,
  • Aspasia Ploubidou,
  • Peter Herrlich

DOI
https://doi.org/10.1038/s41467-021-26057-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.