Frontiers in Neuroanatomy (Dec 2015)
Incomplete Hippocampal Inversion: a comprehensive MRI study of over 2000 subjects
- Claire eCury,
- Claire eCury,
- Claire eCury,
- Claire eCury,
- Claire eCury,
- Claire eCury,
- Roberto eToro,
- Roberto eToro,
- Fanny eCohen,
- Fanny eCohen,
- Fanny eCohen,
- Fanny eCohen,
- Fanny eCohen,
- Clara eFischer,
- Clara eFischer,
- Amel eMhaya,
- Amel eMhaya,
- Amel eMhaya,
- Amel eMhaya,
- Amel eMhaya,
- Jorge eSamper-Gonzalez,
- Jorge eSamper-Gonzalez,
- Jorge eSamper-Gonzalez,
- Jorge eSamper-Gonzalez,
- Jorge eSamper-Gonzalez,
- Dominique eHasboun,
- Dominique eHasboun,
- Dominique eHasboun,
- Dominique eHasboun,
- Dominique eHasboun,
- Dominique eHasboun,
- Jean-Francois eMangin,
- Jean-Francois eMangin,
- Tobias eBanaschewski,
- Arun L. W. Bokde,
- Uli eBromberg,
- Christian eBuechel,
- Christian eBuechel,
- Anna eCattrell,
- Anna eCattrell,
- Patricia eConrod,
- Patricia eConrod,
- Herta eFlor,
- Jürgen eGallinat,
- Hugh eGaravan,
- Hugh eGaravan,
- Penny eGowland,
- Andreas eHeinz,
- Bernd eIttermann,
- Hervé eLEMAITRE,
- Jean-Luc eMartinot,
- Frauke eNees,
- Marie Laure ePaillere,
- Marie Laure ePaillere,
- Dimitri ePapadopoulos Orfanos,
- Tomas ePaus,
- Tomas ePaus,
- Luise ePoustka,
- Luise ePoustka,
- Michael N Smolka,
- Henrik eWalter,
- Henrik eWalter,
- Robert eWhelan,
- Robert eWhelan,
- Vincent eFrouin,
- Gunter eSchumann,
- Gunter eSchumann,
- Joan Alexis Glaunès,
- Olivier eColliot,
- Olivier eColliot,
- Olivier eColliot,
- Olivier eColliot,
- Olivier eColliot,
- Olivier eColliot,
- Olivier eColliot
Affiliations
- Claire eCury
- Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris
- Claire eCury
- Centre d'Acquisition et de Traitement des Images (CATI)
- Claire eCury
- CNRS, UMR 7225
- Claire eCury
- Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127
- Claire eCury
- 4Institut du Cerveau et de la Moelle épinière, ICM
- Claire eCury
- Inria, Aramis team, Centre de Recherche Paris-Rocquencourt
- Roberto eToro
- CNRS, Genes, synapses and cognition, URA 2182, Institut Pasteur
- Roberto eToro
- Institut Pasteur, Human Genetics and Cognitive Functions
- Fanny eCohen
- Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris
- Fanny eCohen
- CNRS, UMR 7225
- Fanny eCohen
- Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127
- Fanny eCohen
- 4Institut du Cerveau et de la Moelle épinière, ICM
- Fanny eCohen
- Inria, Aramis team, Centre de Recherche Paris-Rocquencourt
- Clara eFischer
- CEA, DSV, I2BM, Neurospin, bat. 145
- Clara eFischer
- Centre d'Acquisition et de Traitement des Images (CATI)
- Amel eMhaya
- Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris
- Amel eMhaya
- CNRS, UMR 7225
- Amel eMhaya
- Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127
- Amel eMhaya
- 4Institut du Cerveau et de la Moelle épinière, ICM
- Amel eMhaya
- Inria, Aramis team, Centre de Recherche Paris-Rocquencourt
- Jorge eSamper-Gonzalez
- Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris
- Jorge eSamper-Gonzalez
- CNRS, UMR 7225
- Jorge eSamper-Gonzalez
- Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127
- Jorge eSamper-Gonzalez
- 4Institut du Cerveau et de la Moelle épinière, ICM
- Jorge eSamper-Gonzalez
- Inria, Aramis team, Centre de Recherche Paris-Rocquencourt
- Dominique eHasboun
- Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris
- Dominique eHasboun
- AP-HP, Hôpital de la Pitié-Salpétrière
- Dominique eHasboun
- CNRS, UMR 7225
- Dominique eHasboun
- Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127
- Dominique eHasboun
- 4Institut du Cerveau et de la Moelle épinière, ICM
- Dominique eHasboun
- Inria, Aramis team, Centre de Recherche Paris-Rocquencourt
- Jean-Francois eMangin
- CEA, DSV, I2BM, Neurospin, bat. 145
- Jean-Francois eMangin
- Centre d'Acquisition et de Traitement des Images (CATI)
- Tobias eBanaschewski
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Arun L. W. Bokde
- Institute of Neuroscience, Trinity College Dublin
- Uli eBromberg
- Universitaetsklinikum Hamburg Eppendorf
- Christian eBuechel
- Universitätsklinikum Hamburg Eppendorf
- Christian eBuechel
- Stanford University
- Anna eCattrell
- Institute of Psychiatry, King’s College London
- Anna eCattrell
- MRC Social
- Patricia eConrod
- Institute of Psychiatry, King’s College London
- Patricia eConrod
- Université de Montreal, CHU Ste Justine Hospital
- Herta eFlor
- Medical Faculty Mannheim, Heidelberg University
- Jürgen eGallinat
- Universitätsklinikum Hamburg Eppendorf
- Hugh eGaravan
- Institute of Neuroscience, Trinity College Dublin
- Hugh eGaravan
- Department of Psychiatry, University of Vermont
- Penny eGowland
- School of Physics and Astronomy, University of Nottingham
- Andreas eHeinz
- Campus Charité Mitte, Charité–Universitätsmedizin
- Bernd eIttermann
- Physikalisch-Technische Bundesanstalt (PTB)
- Hervé eLEMAITRE
- INSERM Unit 1000 Neuroimaging and Psychiatry, University Paris sud, University Paris Descartes
- Jean-Luc eMartinot
- INSERM Unit 1000 Neuroimaging and Psychiatry, University Paris sud, University Paris Descartes
- Frauke eNees
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Marie Laure ePaillere
- INSERM Unit 1000 Neuroimaging and Psychiatry, University Paris sud, University Paris Descartes
- Marie Laure ePaillere
- AP-HP, Maison de Solenn, Cochin Hospital, University Paris Descartes, Sorbonne Paris Cité
- Dimitri ePapadopoulos Orfanos
- CEA, DSV, I2BM, Neurospin, bat. 145
- Tomas ePaus
- Rotman Research Institute, University of Toronto
- Tomas ePaus
- Child Mind Institute
- Luise ePoustka
- Central Institute of Mental Health, Clinical Faculty Mannheim, University of Heidelberg
- Luise ePoustka
- Medical University of Vienna
- Michael N Smolka
- Technische Universität Dresden
- Henrik eWalter
- Campus Charité Mitte, Charité–Universitätsmedizin
- Henrik eWalter
- Berlin School of Mind and Brain, Humboldt University Berlin
- Robert eWhelan
- Department of Psychiatry, University of Vermont
- Robert eWhelan
- University College Dublin
- Vincent eFrouin
- CEA, DSV, I2BM, Neurospin, bat. 145
- Gunter eSchumann
- Stanford University
- Gunter eSchumann
- Institute of Psychiatry, King’s College London
- Joan Alexis Glaunès
- Université Paris Descartes, Sorbonne Paris Cité
- Olivier eColliot
- Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris
- Olivier eColliot
- Centre d'Acquisition et de Traitement des Images (CATI)
- Olivier eColliot
- AP-HP, Hôpital de la Pitié-Salpétrière
- Olivier eColliot
- CNRS, UMR 7225
- Olivier eColliot
- Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127
- Olivier eColliot
- 4Institut du Cerveau et de la Moelle épinière, ICM
- Olivier eColliot
- Inria, Aramis team, Centre de Recherche Paris-Rocquencourt
- DOI
- https://doi.org/10.3389/fnana.2015.00160
- Journal volume & issue
-
Vol. 9
Abstract
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ2-test, p<10-28). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.
Keywords
