The Application and Challenge of Binder Jet 3D Printing Technology in Pharmaceutical Manufacturing
Xuejun Chen,
Shanshan Wang,
Jie Wu,
Shuwei Duan,
Xiaolong Wang,
Xiaoxuan Hong,
Xiaolu Han,
Conghui Li,
Dongzhou Kang,
Zengming Wang,
Aiping Zheng
Affiliations
Xuejun Chen
Pharmaceutical Experiment Center, College of Pharmacy, Yanbian University, Yanji 133002, China
Shanshan Wang
College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
Jie Wu
Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
Shuwei Duan
Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
Xiaolong Wang
Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
Xiaoxuan Hong
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Xiaolu Han
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Conghui Li
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Dongzhou Kang
Pharmaceutical Experiment Center, College of Pharmacy, Yanbian University, Yanji 133002, China
Zengming Wang
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Aiping Zheng
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Three-dimensional (3D) printing is an additive manufacturing technique that creates objects under computer control. Owing to the rapid advancement of science and technology, 3D printing technology has been widely utilized in processing and manufacturing but rarely used in the pharmaceutical field. The first commercial form of Spritam® immediate-release tablet was approved by FDA in 2015, which promoted the advancement of 3D printing technology in pharmaceutical development. Three-dimensional printing technology is able to meet individual treatment demands with customized size, shape, and release rate, which overcomes the difficulties of traditional pharmaceutical technology. This paper intends to discuss the critical process parameters of binder jet 3D printing technology, list its application in pharmaceutical manufacturing in recent years, summarize the still-open questions, and demonstrate its great potential in the pharmaceutical industry.
