The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

Jing Wang; Pupu Ge; Lihua Qiang; Feng Tian; Dongdong Zhao; Qiyao Chai; Mingzhao Zhu; Rongbin Zhou; Guangxun Meng; Yoichiro Iwakura; George Fu Gao; Cui Hua Liu

doi:10.1038/s41467-017-00279-z

Nature Communications (Aug 2017)

The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

Jing Wang,
Pupu Ge,
Lihua Qiang,
Feng Tian,
Dongdong Zhao,
Qiyao Chai,
Mingzhao Zhu,
Rongbin Zhou,
Guangxun Meng,
Yoichiro Iwakura,
George Fu Gao,
Cui Hua Liu

Affiliations

Jing Wang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Pupu Ge: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Lihua Qiang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Feng Tian: Center for Bioinformatics, Peking University
Dongdong Zhao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Qiyao Chai: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Mingzhao Zhu: CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Rongbin Zhou: Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China
Guangxun Meng: CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Yoichiro Iwakura: Division of Experimental Animal Immunology, Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
George Fu Gao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Cui Hua Liu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-017-00279-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and promotes proliferation and migration of a cancer cell line.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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