Cirugía y Cirujanos (Jan 2022)

Effect of Re-TUR time on recurrence and progression in high-risk non-muscle-invasive bladder cancer

  • Demirhan O. Demir,
  • Omer G. Doluoglu,
  • Ali K. Yildiz,
  • Turgay Kacan,
  • Veli M. Yazar,
  • Arif Demirbas,
  • Berat C. Ozgur

DOI
https://doi.org/10.24875/CIRU.21000905
Journal volume & issue
Vol. 90, no. 92

Abstract

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Objective: We aimed to investigate the significance of time to re-staging transurethral resection (re-TUR) on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer as a prospective randomized study. Methods: The patients were randomly separated into three groups according to Re-TUR timing. In Groups 1, 2, and 3, the time interval between initial and re-TUR was 14-28 days, 29-42 days, and 43-56 days, respectively. Cox regression analysis was used to assess the effect of time from initial TUR to re-TUR on oncological outcomes. Results: Twenty patients in Group 1 (14-28 days), 22 patients in Group 2 (29-42 days), and 29 patients in Group 3 (43-56 days) completed the study. Kaplan–Meier plots showed no differences in recurrence-free survival (RFS) and progression-free survival (PFS) rates between the three groups. Cox regression analysis demonstrated that only tumor number was found to be a prognostic factor on RFS rates. Conclusion: Our prospective study demonstrated that time laps from initial TUR to re-TUR did not significantly affect on RFS and PFS rates.

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