Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus
Shiow-Chyn Huang,
Pei-Wen Wang,
Ping-Chung Kuo,
Hsin-Yi Hung,
Tai-Long Pan
Affiliations
Shiow-Chyn Huang
Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
Pei-Wen Wang
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Ping-Chung Kuo
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Hsin-Yi Hung
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Tai-Long Pan
School of Traditional Chinese Medicine, Chang Gung University; Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D–N (4–14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.
