A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer

Abstract

Tuo Ruan, Weizhen Liu, Kaixiong Tao, Chuanqing Wu Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaCorrespondence: Kaixiong Tao; Chuanqing WuDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaEmail [email protected]; [email protected]: Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.Keywords: gastric cancer, chemotherapy, resistance

Keywords

• gastric cancer
• chemotherapy
• resistance;