Communications Biology (Apr 2023)

Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3

  • Keisuke Sanematsu,
  • Masato Yamamoto,
  • Yuki Nagasato,
  • Yuko Kawabata,
  • Yu Watanabe,
  • Shusuke Iwata,
  • Shingo Takai,
  • Kiyoshi Toko,
  • Toshiro Matsui,
  • Naohisa Wada,
  • Noriatsu Shigemura

DOI
https://doi.org/10.1038/s42003-023-04705-5
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 12

Abstract

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Molecular dynamics simulations and functional assays of the transmembrane domain of the sweet taste receptor subunit, TAS1R3 reveal mechanisms on the allostery of sweet receptor activation or inactivation and pH-dependent sensitivity to saccharin.