Nature Communications (Jan 2021)
circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity
- Botai Li,
- Lili Zhu,
- Chunlai Lu,
- Cun Wang,
- Hui Wang,
- Haojie Jin,
- Xuhui Ma,
- Zhuoan Cheng,
- Chengtao Yu,
- Siying Wang,
- Qiaozhu Zuo,
- Yangyang Zhou,
- Jun Wang,
- Chen Yang,
- Yuanyuan Lv,
- Liyan Jiang,
- Wenxin Qin
Affiliations
- Botai Li
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering
- Lili Zhu
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering
- Chunlai Lu
- Department of Thoracic Surgery, Zhongshan Hospital, Fudan University
- Cun Wang
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Hui Wang
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Haojie Jin
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Xuhui Ma
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Zhuoan Cheng
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering
- Chengtao Yu
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering
- Siying Wang
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Qiaozhu Zuo
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Yangyang Zhou
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Jun Wang
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Chen Yang
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Yuanyuan Lv
- Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Liyan Jiang
- Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University
- Wenxin Qin
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Biomedical Engineering
- DOI
- https://doi.org/10.1038/s41467-020-20527-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Circular RNAs (circRNA) is a class of non-coding RNAs that can regulate gene translation and function. Here the authors show that a circRNA, circNDUFB2, is downregulated in non-small cell lung cancer tissues, and likely contributes to anti-tumor immunity by regulating both degradation of oncoproteins and induction of innate immunity.
