Influence of nanomaterials on stem cell differentiation: designing an appropriate nanobiointerface

Abstract

Ioana Ilie1, Razvan Ilie2, Teodora Mocan3, Dana Bartos4, Lucian Mocan41Department of Endocrinology, 2Department of Microbiology, 3Department of Physiology, 4Third Surgery Clinic, Department of Nanomedicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, RomaniaAbstract: During the last decade, due to advances in functionalization chemistry, novel nanobiomaterials with applications in tissue engineering and regenerative medicine have been developed. These novel materials with their unique physical and chemical properties are bioactive hierarchical structures that hold great promise for future development of human tissues. Thus, various nanomaterials are currently being intensively explored in the directed differentiation of stem cells, the design of novel bioactive scaffolds, and new research avenues towards tissue regeneration. This paper illustrates the latest achievements in the applications of nanotechnology in tissue engineering in the field of regenerative medicine.Keywords: nanotechnology, nanomaterials, tissue engineering, regeneration, stem cell differentiation