The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Prateek Sharma; James R. J. Haycocks; Alistair D. Middlemiss; Rachel A. Kettles; Laura E. Sellars; Vito Ricci; Laura J. V. Piddock; David C. Grainger

doi:10.1038/s41467-017-01405-7

Nature Communications (Nov 2017)

The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Prateek Sharma,
James R. J. Haycocks,
Alistair D. Middlemiss,
Rachel A. Kettles,
Laura E. Sellars,
Vito Ricci,
Laura J. V. Piddock,
David C. Grainger

Affiliations

Prateek Sharma: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston
James R. J. Haycocks: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston
Alistair D. Middlemiss: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston
Rachel A. Kettles: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston
Laura E. Sellars: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston
Vito Ricci: Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston
Laura J. V. Piddock: Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston
David C. Grainger: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston

DOI: https://doi.org/10.1038/s41467-017-01405-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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