Association between maternal multimorbidity and neurodevelopment of offspring: a prospective birth cohort study from the Japan Environment and Children’s Study
Zentaro Yamagata,
,
Takeo Nakayama,
Chihiro Miyashita,
Reiko Kishi,
Nobuo Yaegashi,
Satoru Takahashi,
Shuichi Ito,
Hidekuni Inadera,
Michihiro Kamijima,
Yukihiro Ohya,
Koichi Hashimoto,
Chisato Mori,
Masayuki Shima,
Narufumi Suganuma,
Takahiko Katoh,
Tomotaka Sobue,
Shin Yamazaki,
Yukihiro Sato,
Yoshiya Ito,
Yasuhito Kato,
Sachiko Ito,
Yasuaki Saijo,
Eiji Yoshioka,
Kentaro Nakanishi,
Ken Nagaya,
Seiji Kageyama,
Shoichi Ohga,
Takanobu Akagi,
Hiroyoshi Iwata,
Takeshi Yamaguchi
Affiliations
Zentaro Yamagata
School of Medicine, Cardiff University, Cardiff, UK
Takeo Nakayama
Chihiro Miyashita
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan
Reiko Kishi
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan
Nobuo Yaegashi
Satoru Takahashi
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan
Shuichi Ito
Hidekuni Inadera
Michihiro Kamijima
Yukihiro Ohya
Koichi Hashimoto
Chisato Mori
Masayuki Shima
Narufumi Suganuma
Takahiko Katoh
Tomotaka Sobue
Shin Yamazaki
Yukihiro Sato
Department of Social Medicine, Asahikawa Medical University, Asahikawa, Japan
Yoshiya Ito
Faculty of Nursing, Japanese Red Cross Hokkaido College of Nursing, Kitami, Japan
Yasuhito Kato
Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan
Sachiko Ito
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan
Yasuaki Saijo
Department of Social Medicine, Asahikawa Medical University, Asahikawa, Japan
Eiji Yoshioka
Department of Social Medicine, Asahikawa Medical University, Asahikawa, Japan
Kentaro Nakanishi
Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan
Ken Nagaya
Division of Neonatology, Perinatal Medical Center, Asahikawa Medical University Hospital, Asahikawa, Japan
Seiji Kageyama
Shoichi Ohga
Takanobu Akagi
Department of Social Medicine, Asahikawa Medical University, Asahikawa, Japan
Hiroyoshi Iwata
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan
Takeshi Yamaguchi
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan
Objectives To investigate the association between multimorbidity during pregnancy and neurodevelopmental delay in offspring using data from a Japanese nationwide birth cohort study.Design This study was a prospective birth cohort study.Setting This study population included 104 059 fetal records who participated in The Japan Environment and Children’s Study from 2011 to 2014.Participants Pregnant women whose children had undergone developmental testing were included in this analysis.Primary and secondary outcome measures Neurodevelopment of offspring was assessed using the Japanese version of the Ages and Stages Questionnaire, third edition, comprising five developmental domains. The number of comorbidities among the pregnant women was categorised as zero, single disease or multimorbidity (two or more diseases). Maternal chronic conditions included in multimorbidity were defined as conditions with high prevalence among women of reproductive age. A multivariate logistic regression analysis was conducted to examine the association between multimorbidity in pregnant women and offspring development.Results Pregnant women with multimorbidity, single disease and no disease accounted for 3.6%, 30.6% and 65.8%, respectively. The ORs for neurodevelopmental impairment during the follow-up period were similar for infants of mothers with no disease comorbidity and those with a single disease comorbidity. However, the ORs for neurodevelopmental impairment were significantly higher for children born to mothers with multimorbidity compared with those born to healthy mothers.Conclusion An association was observed between the number of comorbidities in pregnant women and developmental delay in offspring. Multimorbidity in pregnant women may be associated with neurodevelopmental delay in their offspring. Further research is required in this regard in many other regions of the world.
