Nature Communications (May 2022)
Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C
- Conor McCafferty,
- Tengyi Cai,
- Delphine Borgel,
- Dominique Lasne,
- Sylvain Renolleau,
- Meryl Vedrenne-Cloquet,
- Damien Bonnet,
- Jemma Wu,
- Thiri Zaw,
- Atul Bhatnagar,
- Xiaomin Song,
- Suelyn Van Den Helm,
- Natasha Letunica,
- Chantal Attard,
- Vasiliki Karlaftis,
- Slavica Praporski,
- Vera Ignjatovic,
- Paul Monagle
Affiliations
- Conor McCafferty
- Haematology Research, Murdoch Children’s Research Institute
- Tengyi Cai
- Haematology Research, Murdoch Children’s Research Institute
- Delphine Borgel
- Department of Biological Hematology, Necker Hospital, AP-HP
- Dominique Lasne
- Department of Biological Hematology, Necker Hospital, AP-HP
- Sylvain Renolleau
- Pediatric Intensive Care Unit, Necker Hospital AP-HP
- Meryl Vedrenne-Cloquet
- Pediatric Intensive Care Unit, Necker Hospital AP-HP
- Damien Bonnet
- M3C-Necker, Congenital and Pediatric Cardiology, Necker Hospital, AP-HP
- Jemma Wu
- Australian Proteome Analysis Facility
- Thiri Zaw
- Australian Proteome Analysis Facility
- Atul Bhatnagar
- Australian Proteome Analysis Facility
- Xiaomin Song
- Australian Proteome Analysis Facility
- Suelyn Van Den Helm
- Haematology Research, Murdoch Children’s Research Institute
- Natasha Letunica
- Haematology Research, Murdoch Children’s Research Institute
- Chantal Attard
- Haematology Research, Murdoch Children’s Research Institute
- Vasiliki Karlaftis
- Haematology Research, Murdoch Children’s Research Institute
- Slavica Praporski
- Haematology Research, Murdoch Children’s Research Institute
- Vera Ignjatovic
- Haematology Research, Murdoch Children’s Research Institute
- Paul Monagle
- Haematology Research, Murdoch Children’s Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-29951-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
While rare, SARS-CoV-2-infected children can develop severe COVID-19 (ARDS) or inflammatory syndrome (MIS-C). Here, the authors use proteomics to characterize hundreds of blood proteins and identify key biological pathways that differentiate MIS-C and ARDS.
