Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge <i>Siliquariaspongia japonica</i>

Yasumoto Oyadomari; Yasuyuki Goto; Keisuke Suganuma; Shin-ichiro Kawazu; Leontine E. Becking; Nobuhiro Fusetani; Yoichi Nakao

doi:10.3390/md22040171

Marine Drugs (Apr 2024)

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge <i>Siliquariaspongia japonica</i>

Yasumoto Oyadomari,
Yasuyuki Goto,
Keisuke Suganuma,
Shin-ichiro Kawazu,
Leontine E. Becking,
Nobuhiro Fusetani,
Yoichi Nakao

Affiliations

Yasumoto Oyadomari: Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
Yasuyuki Goto: Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Keisuke Suganuma: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Japan
Shin-ichiro Kawazu: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Japan
Leontine E. Becking: Aquaculture & Fisheries Group, Wageningen University & Research, P.O. Box 338, Bode 32, 6700 AH Wageningen, The Netherlands
Nobuhiro Fusetani: Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
Yoichi Nakao: Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan

DOI: https://doi.org/10.3390/md22040171
Journal volume & issue: Vol. 22, no. 4
p. 171

Abstract

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A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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